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The Parker Lab @ Scripps Research

Broadly speaking, the Parker Lab seeks to develop chemistry-enabled strategies to investigate human biology and disease pathology. Our research integrates organic synthesis with chemical proteomics and cell/molecular biology to (1) to study how small molecules might regulate, or be designed to regulate, complex biological processes such as immune responses and, (2) illuminate molecular mechanisms that contribute to disease. Our primary objectives are not only to better understand protein function and corresponding disease roles, but also to create chemical tools and technologies that might facilitate the development of new therapeutics. 

Check out our Research and Publications sections for more information.

We are always on the lookout for talented new postdocs, students, research associates and interns, so please checkout our Join Us page for more info!

 
 

 

LAB NEWS

10/2024 Check out our Opinion article about chemical proteomic binding site determination now out Trends in Pharmacological Sciences. Nice work Jacob and Weichao!

09/2024 Congrats to Anny, Roy, and team for their recent story published in ACS Chemical Biology! They expanded our AceTAG platform to PCAF/GCN5 and used this chemical tool box to illuminate the impact of acetylation on p53 function.

08/2024 Check out recent collaborative work with the Fox Lab and Pfizer exploring diaizirine reactivity for PAL studies now out in Chemical Science. Congrats to all of the authors!

05/2024 So proud of our first graduate students to defend and graduate from the Parker Lab! Congratulations Dr. Chen and Dr. Homan!!!!!!!!!!!

05/2024 Check out our recent Primer on small molecule photoaffinity labeling in Nature Reviews Methods Primers. Congrats to Rick and team!

04/2024 Congratulations Inès on being named a 2024 CAS Future Leader!!!

01/2024 Thrilled to share the final version of this story in Nature Chemical Biology! We took on an integrated chemoproteomic approach to develop inhibitors of SLC15A4, characterized their MoA, and validated it as a promising therapeutic target for autoimmune conditions. Quite a journey w/the Teijaro lab! Congrats to the team!

01/2024 Delighted to share our recent work in Nature Chemical Biology on small molecule binding site mapping in cells! Big congrats to Jacob and Weichao for leading this work!

09/2023 A big welcome to our newest member, Clara!

09/2023 Excited to see our collaborative work with the Baran and Lairson Labs on Portimine A out in Nature. Congrats Junchen, Weichao, Steven and Qijia!

08/2023 Welcome to the group, Amina!!!

05/2023 Very excited to welcome Junchen and Roy to the Parker Lab!

04/2023 A big congrats to Jacob on his new position at Belharra Therapeutics!

02/2023 Proud to contribute our review on chemical proteomics and fragment-based ligand discovery to a special issue of Isr J Chem dedicated to the 2022 Wolf Prize winners. Congrats Inés on the great work!

01/2023 Check out our collaborative preprint with the Baran Lab where we deconvolute the MoA of portimine A via chemoproteomics, made possible through their remarkable total synthesis. Big congrats to Junchen, Weichao, Steven, Qijia, Lairson Lab and the rest of the team!

12/2022 A big welcome Qijia, our newest member!

10/2022 Happy to see this collaborative work out with the Huang lab detailing our HMO chemoproteomic studies - congrats team!

10/2022 Excited to share our new preprint with the Teijaro Lab describing the chemoproteomic development of first-in-class functional inhibitors of SLC15A4 - a promising autoimmune/auto-inflammatory target.

09/2022 Anny’s methods chapter in MIE is out. We detail using AceTAG to study protein acetylation. Nice job!

08/2022 Check out our recent work in JACS where we map heme interactions across the proteome, leading to some interesting discoveries! Congrats Rick, Louis and Appaso!

07/2022 Congratulations Inés for being awarded a Ford Foundation Predoctoral Fellowship!!!

07/2022 A big welcome to our newest member, Kaylin!

05/2022 We are excited to welcome our Misaki, our new Lab Manager, to the team!

11/2021 Steven has joined the Parker Lab!

10/2021 Brandon and Woojin have joined the Parker Lab!

09/2021 Our final AceTAG story is now out in JACS! Congrats once again to Anny and Wesley!

08/2021 A big welcome to rotation students Woojin and Brandon!

08/2021 Congrats Rick on being the second student in the Parker Lab to become a Ph.D. candidate!

07/2021 Check out our new preprint describing a strategy to induce acetylation of specific proteins in cells using bifunctional small molecules (AceTAG). Congrats to Wesley, Anny and the entire gang!

06/2021 Happy to see collaborative Gal-1 proximity labeling studies out in print @ACS ChemBio with the Huang Lab - congrats Zach et al!

06/2021 The Parker Lab receives its first NIH R01 grant! We are grateful for their support.

06/2021 Huge congrats to Anny, she is the first student in the Parker Lab to take and pass qualifying exams!

06/2021 Excited to welcome rotation student Steven and SURF student Taylor!

05/2021 Congratulations to Louis, Appaso, Rick and team on their recent manuscript in Chemical Science evaluating diazirine tags for chemoproteomic studies.

04/2021 Check out collaborative work in PNAS with the Arora Lab (NYU), who developed a Sos proteomimetic pan-Ras inhibitor.

03/2021 Excited to welcome Christian, who joined the lab for his postdoctoral studies!

02/2021 Congrats to Louis and Weichao on their new review in Cell Chemical Biology about chemoproteomic-enabled phenotypic screening!

12/2020 Photoaffinity fragment probes can be used to develop small molecules that target RNA! Check out collaborative studies in PNAS with the Disney Lab.

10/2020 Take a look at recent collaborative studies in PNAS with the Huang Lab mapping glycan-GBP interactions.

10/2020 Congrats to Rick for receiving a fellowship from the STSI/NIH Clinical Translational Science Award TL1 Training program!

09/2020 A big welcome to Inés, who has recently joined the lab!

08/17/2020 Chris will be giving a virtual seminar about our work tackling SLCs at the ACS meeting in the MEDI division, check it out!

07/2020 A big welcome to Jacob, who will be a joint postdoc between the Parker and Teijaro Labs! And also congrats on his Scripps Immunology Postdoctoral Training Grant!!!

07/2020 Congrats to Wesley for winning “best presentation" award by a postdoc” in our Chemistry department seminar series!

07/2020 Welcome new rotation students Abbey and Inés!

03/2020 Happy to announce the Parker Lab has received an Idea Development Award from the DoD to identify druggable vulnerabilities in KRAS-driven lung cancers!

02/2020 Take a look at the Cell Primer written by Chris and Matt Pratt (USC) about the use of click chemistry in proteomics studies of small molecules and PTMs.

02/2020 Welcome rotation student Adrianna and BLEU intern Michael!

01/2020 A big welcome to Rick Homan, who recently joined the lab!

11/2019 Check out our Perspective in J Med Chem, “The Druggability of Solute Carriers.” Big congrats to Wesley and team for all of their hard work!

11/2019 We are excited to welcome Anny to the lab (officially)!

11/2019 Check out our recent collaborative work using “enantioprobes” to expedite the discovery druggable proteins in Nature Chem

10/2019 Excited to welcome Louis to the lab!

08/2019 Hayden co-won the SURF program poster prize and a travel award for a national conference - Congrats!

08/2019 We are excited to host our first rotation students! Welcome Hamish, Li-Yun, and Rick!

06/2019 A big welcome to SURF intern Hayden Anderson from Trinity!

04/2019 Welcome visiting grad students Alex Berkowitz (Murelli Lab, Brooklyn College) and Andre Leon (Ward Lab, Scripps)!

01/2019 We continue to grow - a big welcome to our new postdoc, Wesley, from Texas A&M and FAU intern, Juanita!

11/2018 A big welcome to our newest member, Leo!

10/2018 The lab is growing, welcome Appaso and Rick!

08/19/2018   Chris will be giving a talk at the ACS National Meeting in Boston, stop by!

08/2018   Renovations are in progress but the Parker Lab is open for business @ Scripps Research!

07/2018 Follow us on Twitter!