Publications
* co-corresponding authors; # authors contributed equally to this work
2024
Wozniak, J.M.#; Li, W.#; Parker, C.G. “Chemical proteomic mapping of reversible small molecule binding sites in native systems,” 2024, Trends Pharm Sci, In Press
Reeves, A.E.; Vilen, Z.V.; Fuentecilla, T.R.; Parker, C.G.; Huang, M. L. “Charting the dynamic trophoblast plasma membrane identifies LYN as a functional regulator of syncytialization,” 2024, ACS Chem Biol, In Press
Chen, L-Y.#, Roy, S.J.S.#, Jadhav, A. M.; Wang, W.W.; Chen, P-H.; Bishop, T.; Erb, M.A.; Parker, C.G. “Functional investigations of p53 acetylation enabled by heterobifunctional molecules,” ACS Chem Biol, 2024, In Press
O’Brien, J.G.K#; Conway, L.P.#; Ramaraj, P.K.; Jadhav, A.M.; Jin, J.; Dutra, J.K.; Evers, P.; Masoud, S.S.; Schupp, M.; Saridakis, I.; Chen, Y.; Maulide, N.; Pezacki, J.P.; am Ende, C.W.*; Parker, C.G.*; Fox, J.M.* “Mechanistic differences between linear vs spirocyclic dialkyldiazirines probes for photoaffinity labeling,” Chemical Science, 2024, In Press.
Homan, R.A.; Lapek, J.D.; Woo, C.M.; Niessen, S.; Jones, L.H.; Parker, C.G. “Photoaffinity labelling with small molecules,” Nature Rev Methods Primers, 2024, 4, 30
Chiu, T-Y.#; Lazar, D.C.#; Wang, W.W.#; Li, W.; Jadhav, A.M.; Wozniak, J.M.; Gazaniga, N.; Theofilopoulous, A.N.; Teijaro, J.R.; Parker, C.G. “Chemoproteomic development of SLC15A4 inhibitors with anti-inflammatory activity”, Nature Chem Biol, 2024, 20, 1000
• bioRxiv preprint, 2022, doi.org/10.1101/2022.10.07.511216
• Highlighted in Nature Chem Biol News & Views and Nature Reviews Drug Discovery
Wozniak, J.M.#; Li, W.#; Governa, P.; Chen, L.Y.; Jadhav A. J.; Dongre, A.; Forli, S.; Parker, C.G. “Enhanced Mapping of Small Molecule Binding Sites in Cells,” Nature Chem Biol, 2024, 20, 823
2023
Wichroski, M.; Benci, J.; Liu, S.; Chupak, L.; Fang, J.; Cao, C.; Wang, C.; Russo, J.; Qiu, H.; Shan, Y.; Banas, D.; Poweles, R.; Locke, G.; Witt, A.; Stromko, C.; Qi, H.; Zheng, X.; Martin, S.; Ding, M.; Gentles, R.; Meanwell, N.; Velaparthi, U.; Olson, R.; Wee, S.; Tenney, D.; Parker, C.G.; Cravatt, B.F.; Lawrence, M.; Borzilleri, R.; Lees, E. “DGKa/z Inhibitors Combine With PD-1 Checkpoint Therapy To Induce Robust T Cell-Mediated Anti-Tumor Immunity,” Sci Trans Med, 2023, 15, eadh1892
Tang, J.#; Li, W.#; Chiu, T-Y.; Luo, Z.; Chong, C. T.; Wei, Q.; Martínez-Peña, F.; Gazaniga, N.; See, Y. Y.; Lairson, L. L.*; Parker, C.G.;* Baran, P. S.* “Synthesis of Portimines Reveals the Basis of their Anti-cancer Activity,” Nature, 2023, 622, 507
ChemRxiv preprint, 2023, doi.org/10.26434/chemrxiv-2023-w286t
Forrest, I.; Parker, C.G. “Proteome-Wide Fragment-Based Ligand and Target Discovery,” Isr J Chem, 2023, e202200098
Fernández Vega, V.; Yang, D.; Ortiz Jordán, L.; Ye, F.; Conway, L.; Chen, L.Y.; Shumate, J.; Baillargeona, P.; Scampavia, L.; Parker, C.G.; Shen, B.; Spicer, T.P. “Protocol for 3D screening of lung cancer spheroids using natural products,” SLAS Discovery, 2023, 28, 20
Chen, L-Y; Wang, W.W; Wozniak, J, Parker, C.G. “A Heterobifunctional Molecule System for Targeted Protein Acetylation in Cells,” Methods Enzymol, 2023, 681, 287
2022
Hassan, A.A.#; Wozniak, J.M.#; Jadhav, A.J.; Li, W.; Vilen, Z.; Parker, C.G.*; Huang, M.L.* “Chemoproteomic Identification of Human Milk Oligosaccharide Targets in Live Cells,” RSC Chemical Biology, 2022, 3, 1369 (Invited submission for chemical proteomics themed collection)
Homan, R.; Jadhav, A.; Conway, L.; Parker, C.G. “A Chemical Proteomic Map of Heme-Protein Interactions” J Am Chem Soc, 2022, 144, 15013
Rimann, I.; Gonzalez-Quintial, R.; Baccala, R.; Kiosses, W.B.; Teijaro, J.R.; Parker, C.G.; Li, X.; Beutler, B.; Kono, D.H.; Theofilopoulous, A.N. “The Solute Carrier SLC15A4 is Required for Optimal Trafficking of Nucleic Acid-Sensing TLRs and Ligands to Endolysosomes” Proc Natl Acad Sci, 2022, 119, e2200544119
2021
Wang, W.W.#; Chen, L-Y#; Wozniak, J.M.; Jadhav, A.M.; Anderson, H.; Malone, T.M.; Parker, C.G. “Targeted Protein Acetylation in Cells Using Heterobifunctional Molecules,” J Am Chem Soc, 2021, 143, 16700
bioRxiv preprint, 2021, doi.org/10.1101/2021.07.27.454011
Vilen, Z.; Joeh, E.; Critcher, M.; Parker, C.G.; Huang, M.L. “Proximity tagging identifies the glycan-mediated glycoprotein interactors of galectin-1 in muscle stem cells” ACS Chem Biol, 2021, 16, 1994
Conway, L. P.#; Jadhav, A.M.#; Homan, R. A.#; Li, W.; Rubiano, J.S.; Hawkins, R.; Lawrence, R.M.; Parker, C.G. “Evaluation of Fully-Functionalized Diazirine Tags for Chemical Proteomic Applications”, Chemical Science, 2021, 12, 7839
Hong, S.H. #; Yoo, D.Y. #; Conway, L.; Richards-Cork K.C.; Parker, C.G.; Arora, P.S. “A Sos Proteomimetic as a Pan-Ras Inhibitor” Proc Natl Acad Sci, 2021, 118, e2101027118
Joeh, E.; Reeves, A.E.; Parker, C.G.; Huang, M.L. “Mapping Glycan to Glycan Binding Protein (GBP) Interactions by Live Cell Proximity Tagging” Curr Prot in Chem Biol, 2021, 117, 27329
Conway, L. C.; Li, W.; Parker, C.G. “Chemoproteomic-Enabled Phenotypic Screening” Cell Chemical Biology; 2021, 28, 371
2020
Suresh, B.M.; Li, W.; Zhang, P.; Wang, K.W.; Yildirim, I.; Parker, C.G.; Disney, M.D. “A general fragment-based approach to identify and optimize bioactive ligands targeting RNA” Proc Natl Acad Sci, 2020, 117, 33197
Joeh, E.; O'Leary, T.; Li, W; Hawkins, R.; Hung, J.; Parker, C.G.; Huang, M.L. “Mapping glycan-mediated galectin-3 interactions by live cell proximity labeling” Proc Natl Acad Sci, 2020, 117, 27329.
bioRxiv preprint, 2020, doi.org/10.1101/2020.05.09.058586
Parker, C.G.*; Pratt, M.R.* “Click Chemistry in Proteomic Investigations” Cell, 2020, 180, 605.
Wang, W.W.; Gallo, L.; Jadhav, A.; Hawkins, R.; Parker, C.G. “The Druggability of Solute Carriers” Journal of Medicinal Chemistry, 2020, 63, 3834.
2019
Galmozzi, A.; Kok, B.P.; Kim, A.S.; Montenegro-Burke, J.R.; Lee, J.Y.; Spreafico, R.; Mosure, S.; Albert, V.; Cintron-Colon, R.; Godio, C.; Webb, W.R.; Conti, B.; Solt, L.A.; Kojetin, D.; Parker, C.G.; Peluso, J.J.; Pru, J.K.; Siuzdak, G.; Cravatt, B.F.; Saez, E. “PGRMC2 is an Intracellular Heme Chaperone Critical for Adipocyte Function” Nature, 2019, 575, 138.
Wang, Y.; Dix, M.M.; Bianco, G.; Remsberg, J.R.; Lee, H.Y.; Kalocsay, M.; Gygi, S.P.; Forli, S.; Vite, G.; Lawrence, R.M.; Parker, C.G.*; Cravatt, B.F.* “Expedited Mapping of the Ligandable Proteome Using Fully Functionalized Enantiomeric Probe Pairs” Nature Chemistry, 2019, 11, 1113.
ChemRxiv pre-print (2019-02-25): doi.org/10.26434/chemrxiv.7764638.v1
highlighted online in Science Translational Medicine: In the Pipeline
GRADUATE & POSTDOCTORAL
Parker, C.G.*; Cravatt, B.F.* “Chemistry Takes Center Stage for Identifying Cancer Targetability” Cell, 2018, 173, 815.
Galmozzi, A.#; Parker, C.G.#, Kok, B. P.; Cravatt, B.F.; Saez, E. “Discovery of Modulators of Adipocyte Physiology Using Fully Functionalized Fragments” Methods Mol Biol, 2018, 1787, 115.
McEnaney, P.J.*; Parker, C.G.*; Zhang, A.X.* “Antibody-Recruiting Small Molecules: Synthetic Constructs as Immunotherapeutics,” Annu Rep Med Chem, 2018, 50, 481.
Parker, C. G.*; Kuttruf, C. A.; Galmozzi, A.; Jorgensen, L.; Chein-Hung, Y.; Hermanson, D.H.; Wang, Y.; Perez, M.E.; McKerrall, S.J.; Joslyn, C. J; Duenstl, G.; Felding, J.; Saez, E.; Baran, P.S.*; Cravatt, B.F*. “Chemical Proteomics Identifies SLC25A20 as a Functional Target of the Ingenol Class of Actinic Keratosis Drugs” ACS Central Science, 2017, 3, 1276.
Schonhoft, J.D.#; Monteiro, C.#; Plate, L.; Eisele, Y.S.; Kelly, J.; Boland, D.; Parker, C.G.; Cravatt, B.F.; Berk, J.; Sekijima, Y.; Maurer, M.; Novais, M.; Coelho, T.; Powers, E.T.; Kelly, J.W. “Peptide Probes Detect Misfolded Transthyretin Oligomers in the Plasma of Early Stage Hereditary Amyloidosis Patients” Science Translational Medicine, 2017, 9, eaam7621.
Parker, C. G.*#; Galmozzi, A.#; Wang, Y.; Correia, B. E.; Sasaki, K.; Joslyn, C. J.; Kim, A. S.; Cavallaro, C. L.; Lawrence, M.; Johnson, S. R.; Saez, E.*; Cravatt, B. F.* “Ligand and target discovery by fragment-based screening in human cells” Cell, 2017, 168, 527-541.
Featured in News and Analysis in Nature Reviews Drug Discovery, 2017, 16, 225; as a Research Highlight in Nature Protocols, 2017, 225, 52; recommended on F1000prime as being of special significance; highlighted online in Science Translational Medicine: In the Pipeline (3/2/2017) and in Drug Discovery News; TSRI Top 10 Scientific Breakthroughs of 2017.
Parker, C.G.; Dahlgren, M.K.; Li, D.T.; Jawanda, N.; Shoda, T.; Spasov, K.A.; Domaoal, R.A.; Sutton, R.; Anderson, K.S.; Jorgensen, W.L.; Spiegel, D.A. ”Illuminating gp120–Ligand Recognition through Computationally-Driven Optimization of Antibody-Recruiting Molecules” Chemical Science, 2014, 5, 2311-2317.
Jakobsche, C.E.#; Parker, C.G.# Tao, R.N.; Kolesnikova, M.D.; Spiegel, D.A. “Exploring Binding and Effector Functions of Natural Human Antibodies Using Synthetic Immunomodulators” ACS Chemical Biology, 2012, 7, 1139-1151.
McEnaney, P. J.#; Parker, C.G.#; Zhang, A.X.# Spiegel, D.A. “Antibody-Recruiting Molecules: An Emerging Paradigm for Engaging Immune Function in Treating Human Disease” ACS Chemical Biology, 2012, 7, 1139-1151.
Parker, C.G.; Domaoal, R.A.; Anderson, K.S.; Spiegel, D.A. “An Antibody-Recruiting Small Molecule That Targets HIV gp120” J Am Chem Soc, 2009, 131, 16392-16394.
This work was also featured as a spotlight in ACS Chemical Biology, 2009, 4, 975, and was highlighted online by Drug Discovery News, Popular Science, and as ACS Noteworthy Chemistry
